Lasso_1016

doi: 10.1016/j.jbc.2021.100598. PMCID: PMC8102917. PMID: 33781744. The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue. ... Conservation of the lasso motif and P67 at the N terminus.A, alignment of CFTR amino terminus segment (aa 1–109) across multiple species, …

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Sungsanpin (1), a new 15-amino-acid peptide, was discovered from a Streptomyces species isolated from deep-sea sediment collected off Jeju Island, Korea. The planar structure of 1 was determined by 1D and 2D NMR spectroscopy, mass spectrometry, and UV spectroscopy. The absolute configurations of the stereocenters in this compound were …

Jun 20, 2020 · In geotechnical engineering, Zhou and Huang (2018) and Zhou et al. (2020) applied lasso-based regression analysis to building response surfaces for reliability analysis of slopes. Although lasso is commonly used in regression analysis to deal with “over-fitting”, there is another approach that is not based on continuous basis functions. Weighted LASSO variable selection for the analysis of FTIR spectra applied to the prediction of engine oil degradation Pia Pfeiffer, Bettina Ronai, Georg Vorlaufer, Nicole Dörr, Peter Filzmoser Article 104617For the PSA50 model, a penalised logistic regression model using the adaptive least absolute shrinkage and selection operator (LASSO) penalty was considered. Model discrimination was determined using the area under the curve and its 95% CI, and calibration was evaluated by predicting the probability of achieving PSA50.A model is presented for the supervised learning problem where the observations come from a fixed number of pre-specified groups, and the regression coefficients may vary sparsely between groups. The model spans the continuum between individual models ...The computation time (in minutes) for 15,000 iterations and n t = 100 of the Gibbs sampling algorithm, implemented in R (on a MacBook Pro, 2.50 GHz Intel Core i5), for the four Bayesian approaches is approximately 0.135m for Blasso, 0.146m for Balasso, 0.169m for Benet, and 0.163m for NBalasso. The Bayesian lasso (Blasso) was faster …

Jul 1, 2021 · The EEMD–LASSO–QRNN model is an ingenious integration of several single methods. EEMD is used to decompose intricate original data into several sample subseries. Each subseries with the optimal parameters promises a more superior performance. KDE is used to realize wind power deterministic and probabilistic forecasts.Sep 1, 2022 · Thresholding estimators such as the existing square-root and LAD LASSO, and the new affine and GLM LASSO with new link functions, have the ability to set coefficients to zero. They will yield new pivotal statistics which enjoy high power under sparse or dense alternative hypotheses.Time-varying Group Lasso Granger Causality Graph for High Dimensional Dynamic system. Wei Gao, Haizhong Yang. Article 108789. View PDF. Article preview. Read the latest articles of Pattern Recognition at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature.Abstract. Group lasso is a natural extension of lasso and selects variables in a grouped manner. However, group lasso suffers from estimation inefficiency and selection inconsistency. To remedy these problems, we propose the adaptive group lasso method. We show theoretically that the new method is able to identify the true model consistently ...A unified fused Lasso approach for sparse and blocky feature selectionin regression and classification. Submit to journal. In this paper, LADMM is designed to solve quantile fused Lasso classification and regression R codes for implementing LADMM in the "LADMM for qfLasso.zip".Paulino Vigil-De Gracia 1 , Martin Lasso, Esteban Ruiz, Juan Carlos Vega-Malek, Flor Tem de Mena, Juan Carlos López; or the HYLA treatment study Affiliation 1 The Obstetric Intensive Unit, Department of Gynecology and Obstetrics, Complejo Hospitalario "Arnulfo Arias Madrid" Caja de Seguro Social, Apartado Postal 87 32 24, Zona 7, Panamá ...Dec 15, 2021 · 100 6 Theory for the Lasso. so-called margin condition, which is the behavior of the theoretical risk near its minimizer. Section 6.5 provides a benchmark for how good empirical risk minimizers. behave if one knows the relevant variables. Section 6.6 gives conditions for consistency.

Jul 2, 2020 · Findings. A total of 2529 patients with COVID-19 was retrospectively analyzed, and 452 eligible severe COVID-19 were used for finally analysis. In training cohort, the median age was 66•0 years while it was 73•0 years in non-survivors. Patients aged 60–75 years accounted for the largest proportion of infected populations and mortality toll. WIFI button. Press - Sounds beep and Initiates SoftAP mode. Hold for 10 seconds - Sounds beep and deletes current SSID and Password. Then initiates SoftAP provisioning mode. After the 1 hour timeout the unit will no longer sign into the last known SSID and Password.Lasso peptides belong to a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) whose biosynthetic enzymes and precursor peptides are readily identified through bioinformatic analysis (Arnison et al., 2013). The biosynthesis of highly-ordered lasso topologies like that of STM is a compelling topic of study because ...Section snippets Numerical model. The analysis is performed with the commercial finite element code ABAQUS™ (Hibbitt et al., 2001) reproducing EPB tunnelling with the model proposed by Ochmański et al. (2018) where computation is governed in a fully automated way by a script developed in Python™ language.Good for newcomers. Extra attention is needed. This doesn't seem right. question. Further information is requested. wontfix. This will not be worked on. Linearized ADMM Algorithm for quantile fused Lasso classification and regression - Labels · xfwu1016/LADMM-for-qfLasso.

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Complete. By continuing, I agree to the UPS Technology Agreement. will open in a new window. Continue Forgot Username/Password.A Bayesian approach for ridge and lasso models based on empirical likelihood is proposed. This method is semiparametric because it combines a nonparametric model and a parametric model. Hence, problems with model misspecification are avoided. Under the Bayesian empirical likelihood approach, the resulting posterior distribution lacks a closed ...Under Mr. Lasso’s watch, violent deaths soared, reaching 4,600 in 2022, the country’s highest in history and double the total in 2021. The National Police tallied 3,568 violent deaths in the ...7380 SPOUT SPRINGS RD. FLOWERY BRANCH, GA 30542. Inside THE UPS STORE. (770) 967-4760. View Details Get Directions. UPS Access Point®. Closed until tomorrow at 7:30am. Latest drop off: Ground: 5:00 PM | Air: 5:00 PM.Identifying homogeneous subgroups of variables can be challenging in high dimensional data analysis with highly correlated predictors. The generalized fused lasso has been proposed to simultaneously select correlated variables and identify them as predictive clusters (grouping property). In this article, we study properties of the generalized fused …

Apr 1, 2021 · The LASSO regression (Tibshirani, 1996), which incorporates a penalty item (L 1) in linear regression, can force some of the coefficient estimations to exactly equal 0 with a sufficiently large tuning parameter. This means that LASSO can automatically select the most important independent variables by shrinking the less important predictors to 0.The WLAD-LASSO combines the ideas of WLAD regression method and LASSO method for robustly estimating the regression parameters and selecting the right model. Our limited simulation study showed that the WLAD-LASSO method fares comparably well in terms of simultaneous robust estimation and variable selection and …Nov 26, 2012 · By innovatively using moderate deviation theory for self-normalized sums, we provide convergence rates for the resulting Lasso and post-Lasso estimators that are as sharp as the corresponding rates in the homoscedastic Gaussian case under the condition that logp = o(n 1/3). We also provide a data-driven method for choosing the penalty level ... The speed and resolution at which we can scour the genome for DNA methylation changes has improved immeasurably in the last 10 years and the advent of the Illumina 450K BeadChip has made epigenome-wide association studies (EWAS) a reality. The ... Nov 17, 2016 · We study the adaptive least absolute shrinkage and selection operator (LASSO) for the sparse autoregressive model (AR). Here, the sparsity of the AR model implies some of the autoregression coefficients are exactly zero, that must be excluded from the AR model. We propose the modified Bayesian information criterion (MBIC) as a way of selecting an optimal tuning parameter for the adaptive LASSO ... Sungsanpin (1), a new 15-amino-acid peptide, was discovered from a Streptomyces species isolated from deep-sea sediment collected off Jeju Island, Korea. The planar structure of 1 was determined by 1D and 2D NMR spectroscopy, mass spectrometry, and UV spectroscopy. The absolute configurations of the stereocenters in this compound were …Lasso is a popular machine learning technique used for obtaining sparse models with accurate predictions and enhanced interpretability. Commonly, a limited number of features are capable of capturing a large part of the deviance. Lasso relies on this Pareto-principle (see also ‘bet-on sparsity principle’ in Hastie et al. (2015)).R Pérez-Cano 1 , J J Vranckx, J M Lasso, C Calabrese, B Merck, A M Milstein, E Sassoon, E Delay, E M Weiler-Mithoff. Affiliation 1 Hospital General Universitario Gregorio Maranon, Madrid, Spain. PMID: 22425137 DOI: 10.1016/j.ejso.2012.02.178 Abstract Aims ...编. 在 统计学 和 机器学习 中, Lasso算法 (英語: least absolute shrinkage and selection operator ,又译最小绝对值收敛和选择算子、套索算法)是一种同时进行 特征选择 和 正则化 (数学)的 回归分析 方法,旨在增强 统计模型 的预测准确性和可解释性,最初由 ...

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Run either of the following to download and install Lasso Professional 8.6 and its dependencies: - For 32-bit CentOS: yum install Lasso-Professional-Apache2. - For 64-bit CentOS: yum install Lasso-Professional-Apache2.x86_64. - To install the documentation (optional): yum install Lasso-Documentation.Nov 20, 2014 · The Lasso highlights the presence of several peaks which are roughly centered at the same location of peaks obtained via the ridge regression. In the Lasso results, a stronger oscillation of the solution in terms of its average value as well as of the 3σ bounds is also present. This behavior is due to the complex nature of the Li-ion battery ... Note that the Lasso-logistic model is similar to the Lasso-Cox model except for the log likelihood function (the first term in equation ). We use the same strategy as PCLasso to integrate protein complexes into the regularized learning framework (6) and propose a protein complex-based, group Lasso-logistic model (PCLassoLog) to predict the ...Sungsanpin (1), a new 15-amino-acid peptide, was discovered from a Streptomyces species isolated from deep-sea sediment collected off Jeju Island, Korea. The planar structure of 1 was determined by 1D and 2D NMR spectroscopy, mass spectrometry, and UV spectroscopy. The absolute configurations of the stereocenters in this compound were …Lasso is a popular machine learning technique used for obtaining sparse models with accurate predictions and enhanced interpretability. Commonly, a limited number of features are capable of capturing a large part of the deviance. Lasso relies on this Pareto-principle (see also ‘bet-on sparsity principle’ in Hastie et al. (2015)).Rich et al. applied PCA and LDA to analyse a database of over 5000 MSP spectra acquired from approximately 500 dyed textile fibres. 325 Both UV-Vis absorbance and fluorescence spectra were found ...About UPS Open the link in a new window; Recognize a UPS Employee Open the link in a new window; Supply Chain Solutions Open the link in a new window; The UPS Store Open the link in a new window; UPS Jobs Open the link in a new window; UPS Developer Portal Open the link in a new windowRich et al. applied PCA and LDA to analyse a database of over 5000 MSP spectra acquired from approximately 500 dyed textile fibres. 325 Both UV-Vis absorbance and fluorescence spectra were found ...LASSO_1010: "We may have reset your password for added protection, or maybe you mistyped the User ID, email or password. Try entering your information one more time. If that doesn’t work, let’s go ahead and reset your password." LASSO_1009: "We have blocked access to this profile after multiple unsuccessful attempts to log-in.

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The physiological and immune changes that occur during pregnancy are associated with worsened disease outcomes during infection and sepsis. How these perturbations exacerbate inflammation has not been explored. Here, using antibiotic treatment and fecal microbial transfers, we showed that sepsis sus …Isopeptidases have also been identified in prokaryotes that express lasso peptides, or peptides with a knotted conformation established by the presence of a non-main-chain linkage between an acidic amino acid and the peptide's N-terminus to form the knot. (Some lasso peptides also have topological complexity conferred by disulfide bonds .)A model is presented for the supervised learning problem where the observations come from a fixed number of pre-specified groups, and the regression coefficients may vary sparsely between groups. The model spans the continuum between individual models ...Linearized ADMM Algorithm for quantile fused Lasso classification and regression Paper: Xiaofei Wu, Zhimin Zhang and Zhenyu Cui (2022+). A unified fused Lasso approach for sparse and blocky feature selectionin regression and classification. Submit to journal. In this paper, LADMM is designed to solve quantile fused Lasso classification and ...We also investigated the "lasso" helices 1 and 2, which occur immediately upstream of P67. Based on limited proteolysis, pulse chase, and molecular dynamics analysis of full-length CFTR and a series of deletion constructs, we argue that P67L and other maturational processing (class 2) defects impair the integrity of the lasso motif and confer misfolding …The benefits of using the LASSO regression model can be summarised as follows: 1) LASSO adds first order penalty to the regressors and this allows LASSO to select out the relevant predictors for dependent variables (Hastie et al., 2019); 2) The importance of independent variables in terms of the change of parameters of the LASSO model can be ...View details for DOI 10.1016/j.cels.2023.02.001. ... Lasso identified 24 molecular ion signals, which are significant for pixel classification. These ion signals included lipids observed at m/z 200-1,200 and Krebs cycle metabolites observed at m/z 200. Based on these features, ...Nov 15, 2018 · Abstract. In this work, the presence of 20 pharmaceuticals in wastewater from Colombia is investigated. Several widely consumed compounds have been detected in wastewater samples from different origins and geographical areas in Colombia. The studied pharmaceuticals included antibiotics, analgesics and anti-inflammatories, cholesterol … ….

However, it is known that the LASSO selects too many noisy variables. In this paper, we propose a new estimator, the moderately clipped LASSO (MCL), that deletes noisy variables successively without sacrificing prediction accuracy much. Various numerical studies are done to illustrate superiority of the MCL over other competitors.In geotechnical engineering, Zhou and Huang (2018) and Zhou et al. (2020) applied lasso-based regression analysis to building response surfaces for reliability analysis of slopes. Although lasso is commonly used in regression analysis to deal with “over-fitting”, there is another approach that is not based on continuous basis functions.100 6 Theory for the Lasso. so-called margin condition, which is the behavior of the theoretical risk near its minimizer. Section 6.5 provides a benchmark for how good empirical risk minimizers. behave if one knows the relevant variables. Section 6.6 gives conditions for consistency.Dec 23, 2015 · (STM), an antibiotic lasso peptide from Streptomo-nospora alba, and report the genome for its pro-ducing organism. STM-resistant clones of Bacillus anthracis harbor mutations to walR, the gene encod-ing a response regulator for the only known widely distributed and essential two-component signal transduction system in Firmicutes. To the …Nov 26, 2012 · By innovatively using moderate deviation theory for self-normalized sums, we provide convergence rates for the resulting Lasso and post-Lasso estimators that are as sharp as the corresponding rates in the homoscedastic Gaussian case under the condition that logp = o(n 1/3). We also provide a data-driven method for choosing the penalty level ... Jul 2, 2020 · Findings. A total of 2529 patients with COVID-19 was retrospectively analyzed, and 452 eligible severe COVID-19 were used for finally analysis. In training cohort, the median age was 66•0 years while it was 73•0 years in non-survivors. Patients aged 60–75 years accounted for the largest proportion of infected populations and mortality toll. This paper presents the key algorithmic techniques behind CatBoost, a new gradient boosting toolkit. Their combination leads to CatBoost outperforming other publicly available boosting implementations in terms of quality on a variety of datasets. Two critical algorithmic advances introduced in CatBoost are the implementation of ordered boosting ...Non-enzymatic glycation is a post-translational modification of long-lived matrix proteins such as type I collagen. It occurs during aging and leads to the formation of advanced glycation end-products (AGEs). AGE accumulation is associated with severe complications in chronic and age-related diseases. The assessment of modifications …Jun 27, 2021 · LASSO, Ridge, and Elastic Net regression methods were used to select variables to build predictive models. The R freeware version 4.0.2 was used. One out of four children tested positive for malaria (25.04%). The logit models based on selected features by LASSO, Ridge, and Elastic Net contained eleven, fifteen, and thirteen features, respectively. Lasso_1016, Oct 29, 2014 · Identifying homogeneous subgroups of variables can be challenging in high dimensional data analysis with highly correlated predictors. The generalized fused lasso has been proposed to simultaneously select correlated variables and identify them as predictive clusters (grouping property). In this article, we study properties of the generalized fused …, Dec 1, 2022 · Abstract. A new estimator, named S-LASSO, is proposed for the coefficient function of the Function-on-Function linear regression model. The S-LASSO estimator is shown to be able to increase the interpretability of the model, by better locating regions where the coefficient function is zero, and to smoothly estimate non-zero values of the coefficient function. , Database Interaction. One of the primary purposes of Lasso is to perform database actions which are a combination of predefinedand visitor-defined parameters and to format the results of those actions. This section introduces the fundamentals of specifying database actions in Lasso. Inline Database Actions includes full details for how to use ..., Enter your email address and we'll send you a reminder. Registered Email Address. Recover My Username. Back to Log In. Reset or recover your login settings. , A model is presented for the supervised learning problem where the observations come from a fixed number of pre-specified groups, and the regression coefficients may vary sparsely between groups. The model spans the continuum between individual models ..., Sep 5, 2019 · Gorka Lasso 1 , Sandra V Mayer 1 , Evandro R Winkelmann 1 , Tim Chu 2 , Oliver Elliot 2 , Juan Angel Patino-Galindo ... DOI: 10.1016/j.cell.2019.08.005 Abstract While knowledge of protein-protein interactions (PPIs) is critical for understanding virus-host relationships, limitations on the scalability of high-throughput methods have hampered ..., Development of a macrophages-related 4-gene signature and nomogram for the overall survival prediction of hepatocellular carcinoma based on WGCNA and LASSO algorithm Int Immunopharmacol . 2021 Jan;90:107238. doi: 10.1016/j.intimp.2020.107238., Identifying homogeneous subgroups of variables can be challenging in high dimensional data analysis with highly correlated predictors. The generalized fused lasso has been proposed to simultaneously select correlated variables and identify them as predictive clusters (grouping property). In this article, we study properties of the generalized fused lasso. First, we present a geometric ..., 编. 在 统计学 和 机器学习 中, Lasso算法 (英語: least absolute shrinkage and selection operator ,又译最小绝对值收敛和选择算子、套索算法)是一种同时进行 特征选择 和 正则化 (数学)的 回归分析 方法,旨在增强 统计模型 的预测准确性和可解释性,最初由 ... , It's not easy to find the right people to speak with at UPS, but this is the best method we have found: To speak with UPS.com Tier 1 Support on the phone, call 1-800-247-9035. They tend to answer calls quickly, and by using this number, you'll have no phone tree to follow., Obtaining such forecasts from classical time series models has proven a difficult task. Here we propose and compare machine learning models incorporating feature selection,such as LASSO and Random Forest regression with LSTM a deep recurrent neural network, to forecast weekly dengue incidence in 790 cities in Brazil. , www.humanitarianresponse.info, In this paper, westudy the LASSO-type penalized CGMM(GMM with continuum of moment method) estimator for the process of Ornstein-Uhlenbeck type. This LASSO-type estimator is obtained by minimizing the summation of the CGMM object function and a LASSO-type penalty, which is included for model selection. In the …, 2020 Mar;224:113446. doi: 10.1016/j.ijheh.2019.113446. Epub 2019 Dec 28. ... Similar associations were detected using adaptive LASSO and GAM. In addition, results from adaptive LASSO and GAM suggested a super-additive interaction between molybdenum and selenium (both p-values = 0.04)., Sep 15, 2019 · The new penalty term combines fused Lasso and matrix-type fused Lasso. We achieve the strong duality theorem between the double fused Lasso penalized LAD and its dual. Based on it, we design a highly scalable symmetric Gauss–Seidel based Alternating Direction Method of Multipliers (sGS-ADMM) algorithm to solve the dual problem., We performed a Monte Carlo study to evaluate the effect of the number of events per variable (EPV) analyzed in logistic regression analysis. The simulations were based on data from a cardiac trial of 673 patients in which 252 deaths occurred and seven variables were cogent predictors of mortality; the number of events per predictive variable was (252/7 =) …, 10.1016/j.micpath.2021.105069. The high incidence of tuberculosis (TB) has brought serious social burdens and it is urgent to explore the mechanism of TB development. This study was conducted to analyze the role of lncRNA-miRNA-mRNA regulatory network and its contained nodes involved in TB to identify crucial biomarkers for early diagnosis of TB., Oct 1, 2021 · The aim of the study was to investigate the potential associations and interactions of multiple metals with cognitive function in older adults using multi-pollutants approach. A cross-sectional study was conducted in a total of 2879 participants aged ≥ 60 years old. We systematically measured levels of 22 blood metals and used the Mini-Mental ... , Oct 16, 2023 · Lasso ejerció el voto después de participar en las primeras horas de este domingo en la inauguración de los comicios en el CNE, en la capital del país, Quito. En un discurso, el mandatario aseguró que su Gobierno velará por la seguridad, la transparencia y el respeto a la voluntad popular depositada en las urnas., Graphical lasso provides a general solution to reveal the indirect statistic dependence of multiple variables in the high dimensional space. Rather than the undirected relationships, a number of practical problems concern much about …, Nov 26, 2012 · By innovatively using moderate deviation theory for self-normalized sums, we provide convergence rates for the resulting Lasso and post-Lasso estimators that are as sharp as the corresponding rates in the homoscedastic Gaussian case under the condition that logp = o(n 1/3). We also provide a data-driven method for choosing the penalty level ..., However, it is known that the LASSO selects too many noisy variables. In this paper, we propose a new estimator, the moderately clipped LASSO (MCL), that deletes noisy variables successively without sacrificing prediction accuracy much. Various numerical studies are done to illustrate superiority of the MCL over other competitors., It adopts parallel tree boosting approaches. In XGBoost, two special regularization techniques are used to minimize the loss efficiently. One of these is L1 or Lasso regularization technique which not only reduces weight values but also removes some weights from the weight vector. The cost function is optimized as Eq., Please make sure to read the common questions. If you are posting tracking info don't include your tracking number as it contains personal information., View details for DOI 10.1016/j.cels.2023.02.001. ... Lasso identified 24 molecular ion signals, which are significant for pixel classification. These ion signals included lipids observed at m/z 200-1,200 and Krebs cycle metabolites observed at m/z 200. Based on these features, ..., 📈 Ordered Homogeneity Pursuit Lasso for Group Variable Selection - GitHub - nanxstats/OHPL: 📈 Ordered Homogeneity Pursuit Lasso for Group Variable Selection, Jan 1, 2015 · Probe Lasso is implemented as part of suite of functions in the Bioconductor package, ChAMP – an all-in-one analysis pipeline that takes raw methylation data and derives MVPs and DMRs for further investigation. Probe Lasso has considerable advantages over more basic methods of DMR calling, such as sliding-fixed window approaches. , The Lasso min model was selected for detailed analysis; mean R 2 (MAE) of the Lasso min and benchmark models for 1000 repeated cross-validation splits were 0.46 (7.7) and 0.42 (8.0), respectively. Conclusions: Machine learning models based on AI-segmented OCT features and clinical variables at baseline may predict future response to ranibizumab ..., Nov 26, 2012 · By innovatively using moderate deviation theory for self-normalized sums, we provide convergence rates for the resulting Lasso and post-Lasso estimators that are as sharp as the corresponding rates in the homoscedastic Gaussian case under the condition that logp = o(n 1/3). We also provide a data-driven method for choosing the penalty level ..., A Bayesian approach for ridge and lasso models based on empirical likelihood is proposed. This method is semiparametric because it combines a nonparametric model and a parametric model. Hence, problems with model misspecification are avoided. Under the Bayesian empirical likelihood approach, the resulting posterior distribution lacks a closed ... , The fuzzy Lasso method is able to increase the interpretability of the model by eliminating the variables irrelevant to the fuzzy response variables. For this purpose, a fuzzy penalized method was introduced to estimate unknown fuzzy regression coefficients and tuning constant., Lasso peptides are a class of ribosomally synthesized and post-translationally modified natural product which possess a unique lariat knot conformation. The low entropy “threaded” conformation endows lasso peptides with considerable resistance to heat and proteolytic degradation, which are attractive properties for the development of …, Sep 1, 2022 · Thresholding estimators such as the existing square-root and LAD LASSO, and the new affine and GLM LASSO with new link functions, have the ability to set coefficients to zero. They will yield new pivotal statistics which enjoy high power under sparse or dense alternative hypotheses.